Characterize the anisotropic, viscoelastic mechanical properties of the right ventricle in healthy and diseased states
Investigate the biomechanical mechanisms of right ventricle failure in adult and pediatric patients
Develop constitutive models of myocardium viscoelasticity
Develop multiscale models of pulmonary circulation to elucidate the impact of ventricular mechanics on organ function
Vascular Hemodynamics and Biomechanics
Quantify and model disease-driven alterations in vascular biomechanics to uncover mechanistic pathways underlying the progression of cardiovascular disorders such as aneurysms and hypertension.
Elucidate the complex interactions among vortical blood flow, arterial wall mechanics, and biological remodeling processes that drive aneurysm initiation, growth, and rupture risk.
Decode the coupled hemodynamic and mechanical adaptations of the coronary circulation in response to altered cardiac function, providing insights for precision diagnostics and therapeutic intervention.
Tissue and Regenerative Engineering
Engineer next-generation in vitro bioscaffold platforms with precisely tunable mechanical properties that faithfully recapitulate the structure and function of native cardiovascular tissues.
Develop sophisticated bioreactor systems capable of delivering controlled, physiologically relevant dynamic mechanical stimuli to cells and engineered tissues.
Uncover the mechanobiological mechanisms that govern the behavior, differentiation, and remodeling of adult and stem cell populations.
Advance scalable biomanufacturing technologies that accelerate the development of regenerative therapies for cardiovascular disease.
